The global cell-free protein expression market size was US$ 225.09 million in 2021. The global cell-free protein expression market is expected to grow to US$ 451.1 million by 2030 by registering a compound annual growth rate (CAGR) of 8.1% during the forecast period from 2022 to 2030.

Factors Influencing the Market
The global cell-free protein expression market is majorly driven by the increasing R&D in proteomics and genomics and the high prevalence of cancer and infectious diseases. In 2021, nearly 1,898,160 new cancer cases were diagnosed, while 608,570 cancer deaths were registered in the United States. Therefore, it presents potential prospects for the cell-free protein expression market. Moreover, the fact that producers and manufacturers are emphasizing the development of cost-effective and rapid protein expression methods will boost the market growth during the analysis period. 
Cell-free protein expression finds a wide range of applications in the labeling of protein with stable isotopes, production of functional virons or toxic polypeptides, protein stability or protein degradation, and investigations to describe protein-protein interaction and protein-nucleic acid interaction. Therefore, the wide range of applications of cell-free protein expression will fuel the growth of the global market during the analysis period.

Regional Analysis
North America held the largest share in the cell-free protein expression market, owing to the rising prevalence of chronic diseases, such as cancer, combined with the growing geriatric population. Further, growing R&D facilities and favorable government initiatives in the United States to enhance healthcare infrastructure will contribute to the growth of the market during the analysis period. The United States in North America is expected to hold the largest market share due to the rising burden of cancer cases, along with the growing trend of cell-based research in the region. 
The Asia-Pacific cell-free protein expression market is expected to grow significantly due to the presence of a large number of end-use industries, such as pharmaceutical and biotechnological industries, in the region.

COVID-19 Impact Analysis
The COVID-19 pandemic has positively influenced the cell-free protein expression market cell-free protein expression was widely used in the diagnosis of COVID-19 disease. Various types of research were done, which depicted the potential of cell-free protein expression. For instance, biologists at Toronto University eliminated enzymes required for translation from E. coli in order to develop a cell-free expression system. The system can efficiently recognize the parts of the SARS-CoV-2 genome and also triggers a molecular shift to developing reporter protein. The research significantly upsurged the adoption of CFPS in the diagnosis of Covid-19.

Competitors in the Market
• Biotechrabbit GmbH
• CellFree Sciences Co., Ltd.
• Cube Biotech GmbH
• GeneCopoeia, Inc.
• Jena Bioscience GmbH
• Merck KGaA
• New England BioLabs
• Promega Corporation
• Takara Bio Company
• Thermo Fisher Scientific, Inc.
• Other Prominent Players

Market Segmentation
The global cell-free protein expression market segmentation focuses on Products, Applications, Methods, End-Use, and Region. 
By Products
• Expression system
o E. coli
o Wheat germ
o Rabbit reticulocytes
o Insect cells
o Human
o Other
• Reagents
By Applications
• Enzyme engineering
• High throughput production
• Protein labeling
• Protein-Protein interaction
• Protein purification
By Methods
• Transcription and translation system
• Translation systems
By End-Use
• Pharmaceutical and biotechnology companies
• Academic and research institutes
• Others
By Region
• North America
• The U.S.
• Canada
• Mexico
• Europe
• Western Europe
• The UK
• Germany
• France
• Italy
• Spain
• Rest of Western Europe
• Eastern Europe
• Poland
• Russia
• Rest of Eastern Europe
• Asia Pacific
• China
• India
• Japan
• Australia & New Zealand
• ASEAN
• Rest of Asia Pacific
• Middle East & Africa (MEA)
• UAE
• Saudi Arabia
• South Africa
• Rest of MEA
• South America
• Brazil
• Argentina
• Rest of South America